Commemorative Lecture
نویسنده
چکیده
The ob gene was cloned in 1994 using the methodology of positional cloning. Leptin, the protein encoded by the ob gene, was identified in 1995 and shown to be a hormonal signal that regulates energy balance.14 Since its discovery 15 years ago, 30,943 articles on leptin have been written (S Korres, personal communication, 2009), providing an opportunity to assess, with some hindsight, the impact of this research. What follows is a summary of the conclusions that have emerged from this and subsequent research.
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